#cardiac muscle cells

It’s quite likely that most people who end up in the vicinity of a scorpion will more than likely beat a hasty retreat, not least because they can impart a potentially life threatening dose of venom should one get stung.

But scientists are now finding that the venom from these creatures, along with snakes and spiders, could be beneficial in treating heart attacks. Scorpion venom in particular contains a peptide that has been found to have a positive impact on the cardiovascular system of rats with high blood pressure. Reporting their findings in Journal of Proteome Research, scientists from Brazil, Canada and Denmark say that they now have a better understanding of the processes involved.

Emperor Scorpion 

Scorpion venom is a complex mixture of molecules including neurotoxins, vasodilators and antimicrobial compounds, among many others. Individual venom compounds, if isolated and administered at the proper dose, could have surprising health benefits, the researchers say.

One promising compound is the tripeptide KPP (Lys-Pro-Pro), which the researchers say is part of a larger scorpion toxin. KPP was shown to cause blood vessels to dilate and blood pressure to decline in hypertensive rats.

A blood vessel on organic tissue

To understand how KPP worked, the researchers treated cardiac muscle cells from mice, in a Petri dish, with KPP and measured the levels of proteins expressed by the cells at different times using mass spectrometry. They found that KPP regulated proteins associated with cell death, energy production, muscle contraction and protein turnover. In addition the scorpion peptide triggered the phosphorylation of a mouse protein called AKT, which activated another protein involved in production of nitric oxide, a vasodilator.

Treatment with KPP led to dephosphorylation of a protein called phospholamban, which led to reduced contraction of cardiac muscle cells. Both AKT and phospholamban are already known to protect cardiac tissue from injuries caused by lack of oxygen. The researchers said that these results indicate that KPP should be further studied as a drug lead for heart attacks and other cardiovascular problems.

Conceptual image for cardiovascular problems . 

DOI:10.1021/acs.jproteome.0c00290

Written by Muriel Cozier. You can find more of her work here.