#immune system activation

Oddly not mentioned: vaccines, the very definition of immune system activation and Hep B routinely given at birth?

Immune System Activation in Newborns May Affect Developing Brain

McLean Hospital neuroscientists have found that even a brief episode of immune system activation within days of birth can cause persistent changes in sleep patterns concurrent with increases in epilepsy-like brain activity—a combination of symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the January 12, 2018 issue of Neuropsychopharmacology.

“A growing body of evidence suggests that immune system activation, such as that caused by bacterial and viral infections, can play important roles in many brain disorders,” explained Bill Carlezon, PhD, chief of the Division of Basic Neuroscience at McLean Hospital, and senior author of the paper. “While previous research in laboratory animals has established that immune activation during critical prenatal (before birth) developmental periods can later produce the core features of ASD, including decreased social interaction, aberrant communication, and increased repetitive behavior, we wanted to evaluate whether postnatal (during infancy) immune activation could also produce other symptom clusters that are often seen in ASD and related conditions.”

Full open access research for “Perinatal Immune Activation Produces Persistent Sleep Alterations and Epileptiform Activity in Male Mice” by Galen Missig, Emery L Mokler, James O Robbins, Abigail J Alexander, Christopher J McDougle & William A Carlezon Jr in Neuropsychopharmacology. Published online October 6 2017 doi:not available