Tome Sweet TomeThe surfaces of all cells in nature are festooned with a complex and diverse array of

Tome Sweet Tome

The surfaces of all cells in nature are festooned with a complex and diverse array of sugar chains (called glycans). These perform a wide variety of biological functions, from the proper folding of proteins to cell-to-cell interactions. Their ubiquity in nature underscores their essentialness to complex life.

This week, the fourth edition of “Essentials of Glycobiology” (the study of glycans) was published by Cold Spring Harbor Laboratory Press. It’s a continuation and updating of landmark work by a consortium of editors, led by Ajit Varki, MD, Distinguished Professor in the departments of Medicine and Cellular and Molecular Medicine at UC San Diego School of Medicine, with contributions from a number of UC San Diego scientists and physicians, including Jeffrey D. Esko, PhD, Distinguished Professor of cellular and molecular medicine; Pascal Gagneux, PhD, professor of pathology and anthropology, and Kamil Godula, PhD, associate professor of chemistry and biochemistry, and Amanda Lewis PhD, professor of obstetrics-gynecology and reproductive science.

Varki and Esko are also founding directors of the Glycobiology Research and Training Center (GRTC) at UC San Diego, established in 1999, and have recently handed over leadership to Lewis and Godula.

Glycobiology is a relatively new scientific discipline. The term was only coined in 1988, recognizing the combining of carbohydrate chemistry and biochemistry to focus on glycans, which have since proven to have a multitude of diverse and often critical roles in biology.

They have been linked to human origins and as a key evolutionary marker. They are found to both inhibit and promote tumor growth; and the presence of a particular sialic acid in red meat may be linked to increased cancer risk in humans.  Another class of glycans called glycosaminoglycans have been shown by Esko and colleagues to be involved in COVID-19 coronavirus pathogenesis. The cover of the fourth edition presents an all-atom model of infamous spike protein of the pandemic virus, emphasizing the massive array of glycan chains modelled by UC San Diego professor of biology Rommie Amaro.

Varki, Esko and colleagues at the GRTC have been central to many of the advances in glycobiology, and the textbook, which originally debuted in 1999, has been an enduring effort to broadly introduce and describe the rapidly changing discipline.

For example, the second edition of “Essentials of Glycobiology,” published in 2008, appeared simultaneously in print from the Cold Spring Harbor Laboratory Press, and free online to reach a wider audience. Subsequent editions have also been free online at the National Center for Biotechnology Information at the National Library of Medicine.

“This approach ensures that everyone, from the layperson to the high school student to the graduate student in a developing country, has free access to the knowledge the book contains, while increasing awareness of the availability of a printed edition that may be more suitable for some readers’ requirements,” said Varki at the time.

— Scott LaFee

Pictured above: In this electron micrograph, the surface of a bacterium is fuzzy with a coating of glycans.