#as explained by dnd

The vaccine, without a doubt. In DND terms, think of it as a potion that gives you a +15 modifier to your saving throw to avoid getting sick, to avoid spreading it to others, and if you fail the getting sick saving throw, you retain that modifier to avoid severe illness/hospitalization. If you fail THAT roll, you still retain the huge bonus to your death save.Now, some people have very bad immune systems… vaccines are less reliable with those folks, but do still help. And, of course, rolling a 1 is certainly a thing.