#medical technology
Heated magnetic nanoparticles may be the future of eradicating cancer cells without harming healthy tissue, according to research from the University of Buffalo, USA. The nanoparticles strike tumours with significant heat under a low magnetic field.
Hao Zeng, Professor of Physics at Buffalo, said, ‘The main accomplishment of our work is the greatly enhanced heating performance of nanoparticles under low-field conditions suitable for clinical applications. The best heating power we obtained is close to the theoretical limit, greatly surpassing some of the best performing particles that other research teams have produced.’
Targeting technologies would first direct nanoparticles to tumours within the patient’s body. Exposure to an alternating magnetic field would prompt the particles’ magnetic orientation to flip back and forth hundreds of thousands of times a second, causing them to warm up as they absorb energy from the electromagnetic field and convert it to thermal energy.
Two particles have been tested – manganese-cobalt-ferrite and zinc ferrite. While the manganese particle reached maximum heating power under high magnetic fields, the biocompatible zinc ferrite was efficieny under an ultra-low field.
While this form of treatment, known as magnetic nanoparticle hyperthermia, is not new, the Buffalo-designed particles are able to generate heat several times faster than the current standard.
Engineers 3D print flexible mesh for ankle and knee braces
Techniques could lead to personalized wearable and implantable devices
Hearing aids, dental crowns, and limb prosthetics are some of the medical devices that can now be digitally designed and customized for individual patients, thanks to 3-D printing. However, these devices are typically designed to replace or support bones and other rigid parts of the body, and are often printed from solid, relatively inflexible material.
Now MIT engineers have designed pliable, 3-D-printed mesh materials whose flexibility and toughness they can tune to emulate and support softer tissues such as muscles and tendons. They can tailor the intricate structures in each mesh, and they envision the tough yet stretchy fabric-like material being used as personalized, wearable supports, including ankle or knee braces, and even implantable devices, such as hernia meshes, that better match to a person’s body.
As a demonstration, the team printed a flexible mesh for use in an ankle brace. They tailored the mesh’s structure to prevent the ankle from turning inward – a common cause of injury – while allowing the joint to move freely in other directions. The researchers also fabricated a knee brace design that could conform to the knee even as it bends. And, they produced a glove with a 3-D-printed mesh sewn into its top surface, which conforms to a wearer’s knuckles, providing resistance against involuntary clenching that can occur following a stroke.
“This work is new in that it focuses on the mechanical properties and geometries required to support soft tissues,” says Sebastian Pattinson, who conducted the research as a postdoc at MIT.
Faster, larger graphene crystals
© University of Oxford – Comparison of graphene crystals produced on pristine platinum (left) and a silicide liquid layer (right)
Researchers from the Nanomaterials by Design Group at University of Oxford, led by professor Nicole Grobert have produced millimetre-sized crystals of high-quality graphene in minutes, using a chemical vapour deposition technique (CVD).
The new method produces 2–3mm graphene crystals in 15 minutes, compared to current process which can take up to 19 hours.
Researchers took a thin film of silica deposited on a platinum foil which when heated, reacts to create a layer of platinum silicide. This layer melts at a lower temperature than platinum and silica to create a thin liquid layer that smooth’s out nanoscale ‘valleys’ in the platinum, so that carbon atoms in methane gas brushing the surface form large flakes of graphene.
Grobery, said, ‘Not only can we make millimetre-sized graphene flakes in minutes but this graphene is of a comparable quality to any other methods.’
The team believe the CVD technique could also have additional benefits claiming with a thicker liquid layer to insulate it the graphene might not have to be removed from the substrate before it can be used – an expensive and time consuming process.
Grobert added, ‘Of course a great deal more work is required before we get graphene technology, but we’re now on the cusp of seeing this material make the leap from the laboratory to a manufacturing setting, and we’re keen to work with industrial partners to make this happen.
The researchers hope to develop this technique further and produce flakes of graphene in large wafer-sized sheets.
To read the full paper in Nature Communications, visit http://bit.ly/1InnoQQ
In other news:
· Molecular sponge advancement in storing hydrogen
· India to create strategic uranium reserve
· Emissions from fossil fuels may limit carbon dating
· Bionic eye implant is a world first
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