#med lab
✨ Happy Star Wars Day ✨
May the Fourth be with you!
i♡histo
Star Wars histology from top left, clockwise:
1. The Graafian follicle Death Star
In a galaxy far, far away an intergalactic superweapon is halted in metaphase II of meiosis amid a surge in Luteinizing Hormone.
2. Jabba the Corpus Albicans
“makingsa lee ka bok pateesa… beeska chata wnow kong bantha poodoo”
(translation) “you may have been a good friend..but now you are bantha fodder”
The corpus albicans is a structure in the ovary that is formed when the corpus luteum regresses.
3. Tusken Raider in the Liver
Despite what you see here, Tusken Raiders are not native to the human liver. If you think that, then you are making a wookie mistake.
The image is actually a portal triad and demonstrates the major structures that enter and leave the liver: hepatic artery, hepatic portal vein and bile duct.
4. The Empire Strikes Back (at the Liver)
Liver histology is definitely where it’s At-At!
A region of connective tissue among the hepatocytes in the liver.
—
Images by @ihearthisto,@drjohnrajala,@zenonichand@hopkins_gi_pathrespectively
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You can find LOVE in the strangest of places (2022 edition)
By row starting top left:
1. in a skin cylindroma
2. in an hepatic ductule
3. in a pancreas
4. in a warty penile growth
5. in a mucus-y colon
6. in a region of hypodermis
7. in a secondary oocyte
8. in a chondrosarcoma
9. in a small artery
Happy Valentine’s Day
Tag a friend with the histo heart you want to share with them and spread the love!
Images by:
@ihearthisto [1-4, 5-9]
@donna.horncastle [5]
❄️Pappy Holidays❄️
There’s nothing quite like a Pap smear Christmas tree to rock around this happy holiday season!
by the awesome @instapatologia [Insta]
Have a Howelly-Jolly Christmas
A festive finding in the blood of an asplenic patient
A Howell–Jolly body is a cytopathological finding whereby small remnants of nuclear DNA are present in normally anuclear circulating erythrocytes.
During development in the bone marrow, late orthochromatophilic erythroblast normally expel their nuclei. However, in some cases, a small portion of DNA remains (the purple dots in the erythrocytes wearing the Santa hats).
Under normal circumstances if these irregular erythrocytes make it into the blood, they are removed from circulation by the spleen.
As a result, the presence of erythrocytes with Howell-Jolly bodies in peripheral blood smears like this usually signifies a damaged or absent spleen - because a healthy spleen would normally filter this type of red blood cell.
by exlibrisadpugno via reddit
Prostate Snail
A secretory gastropod with a corpus amylaceum shell!
i❤️histo
This image is a close up view of a slice through the prostate gland!
The glandular portion of the prostate is composed of secretory acini that release prostatic fluid into a duct system within the gland. Prostatic fluid is a major component of semen and is rich in protein and sugar that keeps spermatozoa nourished as they travel through the reproductive tract.
The snail’s head and body are composed of the secretory epithelial cells!
The giant shell of the snail is a structure known as a prostatic concretion (corpus amylaceum or starchy body). This is a substance thought to be composed of thickened prostatic secretions and shed cells that is found in the acini and ducts of the prostate gland - it is of unknown significance.
However, these structures do increase in number with age and are a useful identifying feature of prostate in both non-pathological and pathological prostate specimens.
The space between the secretory acini is filled with a mixture of fibrous connective tissue and smooth muscle.
The smooth muscle is important because it contracts during ejaculation to push the prostatic fluid out of the gland and into the prostatic urethra where it mixes with spermatozoa arriving from the testis.
The connective tissue component is important clinically because as people with prostate glands grow older this fibrous tissue can undergo hyperplasia (excessive growth). This growth can constrict the urethra which passes directly through the prostate gland. The urethra, in addition to conveying semen during ejaculation, also carries urine during micturition/urination. This explains some of the symptoms associated with the common disorder, benign prostatic hyperplasia when urination becomes problematic for the elderly.
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![The Organ Rings [Answers] Original post without answers: https://www.ihearthisto.com/post/657148528](https://64.media.tumblr.com/484b98cf82c61d709722bca340d7cc7e/23e52e0dade3875d-bb/s1280x1920/3ce8479fe1e20400e90d61820fce13c514d6a592.jpg "The Organ Rings [Answers] Original post without answers: https://www.ihearthisto.com/post/657148528")
The Organ Rings [Answers]
Original post without answers:
https://www.ihearthisto.com/post/657148528765911040/the-organ-rings-to-commemorate-the-olympic
Trachea: C-shaped cartilage, a pseudostratified epi with cilia & goblet cells
Esophagus: Non-keratinized stratified squamous epi and muscularis mucosa
⚫ Artery (distributing): Prominent internal elastic lamina & thick smooth muscle tunica media
Bladder or Ureter: Transitional epithelium
Appendix: Crypts of Lieberkuhn (no villi) with surrounding submucosal lymph nodules
Thanks for playing!
Enjoy the games!
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The Organ Rings
To commemorate the Olympic Games here are some slices through a few of the more tubular organs in your body!
Do you know what they are? Comment below!
Winner gets the gold medal!
[I’ll post the answers soon!]
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Jurassic Pork
The pork tapeworm Taenia solium or a brachiosaurus?
i♡histo
This image shows the tapeworm T. solium, a parasite found in the bowels of humans who eat under-cooked pork.
You can see the proglottid segments of the worm’s neck/body and its terrifying scolex (head) complete with a hooked rostellum which it uses to attach itself onto your intestinal wall so that you don’t poop it out easily.
Fully grown worms can expand to around 2-3 meters in length and are composed of numerous segments each of which form their own reproductive unit.
The life cycle of the parasite begins when pigs ingest the T. solium eggs (from fecal contamination). The eggs develop into larvae inside the pig & then migrate through the intestinal wall to form cysts in their muscles & tissues.
Once slaughtered for meat, the larvae can be ingested by humans if the pork is eaten raw or under-cooked. Once in the human small intestine the larvae grow into large adult worms where they persist often unnoticed due to the lack of symptoms associated with their existence. The worms lay eggs into the intestines which are released during defecation thus continuing the life cycle.
“Life finds a way” - Dr. Ian Malcolm, Jurassic Park
A major complication of infection with T. solium is Cysticercosis. This is a parasitic tissue infection caused by the larval cysts of the tapeworm. These larval cysts infect brain, muscle, or other tissue, and are a cause of adult onset seizures. A person only gets cysticercosis by swallowing the eggs found in the feces of a person who has an intestinal tapeworm NOT from contracting a tapeworm by eating under-cooked pork itself. So people living in the same household with someone who has a tapeworm have a much higher risk of getting cysticercosis than people who don’t because they can be exposed to the eggs released in the stool.
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Mi-fourth-sis
Dividing pyrotechnics!
Don’t forget to review the stages of mitosis while watching the fireworks this weekend!
It looks like this one is in metaphase!
Happy 4th of July!
A Pacinian Fingerprint at the Scene of the Crime
With all of this criminal activity it’s not surprising the body is full of cells!
A Pacinian or lamellar corpuscle is a mechanoreceptor that is most frequently found at the junction of the dermis/hypodermis in the skin. They are particularly prominent in the skin of the fingers and palms. In addition to the skin they are also found in other organs (e.g. mesentery, pancreas).
These very unique fingerprint-like structures have characteristic whorls formed from concentric lamella. Each lamella is separated from the next by a fluid filled space. And each lamella is lined on its inner and outer surface by connective tissue synthesized by the fibroblasts also in this region (you can see the nuclei of the fibroblasts in these lamellae in this image).
A nerve runs from the inner core of the corpuscle and is responsible for the transduction of mechanical forces applied to the skin into electrical signals that are conveyed to the central nervous system via the dorsal root ganglion.
This organization of fluid filled lamella and a central nerve are highly sensitive to pressure, particularly vibrational forces generated during tasks that involve a manipulative or tactile nature, like sensing the texture of a surface that is touched.
In fact, the screen of the phone/tablet you are using right now has been designed with the specific intention of stimulating the Pacinian corpuscles in your finger as you scroll.
So why not test out the Pacinians of your index finger for a moment by liking this post and following!! :-)
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Mother Earth
A biopsy of the mammary gland obtained during pregnancy.
Let’s celebrate our planet and home!
Happy Earth Day everyone!
i♡histo
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Which came first?
A seasonal conundrum in some keratin debris within a benign lymphoepithelial cyst.
Happy Spring & Happy Easter everyone!
The image shows a swirl of keratin debris (the chicken) in a small epithelial cell nest (the egg). The salivary gland is packed full of lymphocytes (the many, many purple nuclei surrounding the epithelial nest) which are a type of white blood cell.
Salivary gland lymphoepithelial cyst like this are rare and benign. Once the cyst is removed surgically from the gland it rarely recurs.
Dinosmear
A rare sighting of the rawrsome Papanicolaous Rex!
The cells in this image are the squamous epithelial cells that line the region of the ectocervix the region of the hole (os) in the cervix where it protrudes into the vagina.
Doctors obtain these cells by scraping the cervix. The cells are then smeared onto a slide and stained with the Papanicolaou stain during the pap smear. Cytologists examine the cells for any signs of abnormal morphology that could be an indicator of cervical cancer or other pathology.
Image based on the original by @mik__e [Insta]
⭐ Patrick Star in a Sperm Tube
My favorite Patrick in honor of #stpaddysday☘️
Some say that Patrick Star and the male reproductive tract are fairly similar… but if you look closely there’s actually a vas deferens.
This image shows the tube through which spermatozoa travel during ejaculation. It is called the vas deferens (ductus deferens).
Histologically it is unique because of its unique pseudostratified epithelium (surrounding Patrick…check out the unique regular beaded appearance of the basal cells in this epithelium) and its triple-layered smooth muscle wall - so thick you can actually palpate it within the spermatic cord within the scrotum. Patrick is actually within the empty space of the lumen of the tube (where the sperm travels).
Spermatozoa are produced in the seminiferous tubules of the testes and travel to the epididymis where they complete the maturation process. During ejaculation, a peristaltic wave of strong muscular contractions propel the sperm from the epididymis and into the vas deferens. This wave of peristalsis continues along the triple-thick muscle wall of the vas deferens eventually pushing the sperm out into the urethra. From here they have enough momentum to travel along the length of the penis before exiting exit the tube at the external urethral meatus (the fancy anatomical name for the hole at the end of the penis).
But sperm are not the only stuff that is ejaculated… at the same time as the sperm is moving along this pathway, the smooth muscle surrounding a number of glands also contracts which pushes their secretions into the urethra too at the same moment that the sperm is moving through it. These include secretions from the seminal vesicles (seminal fluid), prostate gland (prostatic fluid) and bulbourethral glands.
The final concoction that is ejaculated is actually a combination of sperm and all of these extra sperm-nourishing secretions and collectively it is known as semen.
Which brings us back to where we started with this sea-man - Patrick Star!
#histology #science #pathology #pathologists #anatomy #autopsy #patrickstar #spongebob #vasdeferens #malereproductive #stpatricksday #menshealth #premed #biology #medicaleducation #meded #nurse #nursing #medschool #medstudent #medicine #medlab #vetscience #vetschool #ihearthisto
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The Ro-lung Stones
The Stones’ ‘Hot Lips’ logo formed from a blood vessel filled with erythrocytes within a congested zone around a focal pneumonia of the lung.
During the first stages of focal/lobar pneumonia macrophages (the larger cells that are visible in the white alveolar space) respond to phagocytose (eat) any pathogens in the lung.
Additionally, the small blood vessels within the lung tissue begin to engorge (you can see all the erythrocytes in the dilated vessels not only in the large 'hot lips’ vessel but the smaller vessels in the interalveolar septa between adjacent alveoli). This is the congestion phase.
With this dilation of vessels come more white blood cells, you can see numerous neutrophils (they are the small cells that look like they have multiple lobes to their purple nuclei) have migrated out of the vessels (a process called extravasation) into the surround tissue and alveolar spaces. These cells are signs of an additional immune response and they help the macrophages destroy pathogens in the airway.
Image is by @beautiful_pathologist - check out her Instagram for more histology.
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Santa Larvae
Hurry down my cecum tonight!
A nematode larva (Contracaecum) in the digestive tract of a seal. The eggs of this parasitic nematode use fish as an intermediate host before infecting piscivorous mammals, including humans who may forget to clean their holiday salmon!
This festive image was captured by veterinary pathologist @velphegor_vetpath via Instagram.
Happy holidays everyone!
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Blobfish-face
A coronal section through a developing jaw (when flipped upside down) looks like poor old blobfish!
The blobfish eyes are formed from Meckel’s cartilage. A component of the first pharyngeal arch that runs the length of the developing mandible. It degenerates as the fetus develops leaving only two small components on each side of the head. These ossify (become bone) to form the incus & malleus (ear ossicles) of the middle ear.
The blobfish nose is the developing tongue. It is composed of developing skeletal muscle fibers. Skeletal muscle forms from myoblasts that line up & fuse to form long myotubes. These will then synthesize actin/myosin which will allow them to contract & form the intrinsic skeletal muscle of the tongue.
The blobfish chin is formed by the developing maxilla. Two regions of tissue (the palatine shelves) grow together & fuse in the midline to form the posterior hard palate. You can see the midline suture forming & feel it in your own mouth by running your tongue along the roof of your mouth. Failure of these to fuse results in a variety of cleft lip and palate combinations.
The blobfish head is formed from a developing mandible. You can see small islands of bone forming within the mesenchymal tissue of the head. This type of bone development is called intramembranous ossification.
The blobfish is native to coastal waters off mainland Australia and Tasmania where it lives way deep down in the darkest depths of the ocean. Its gelatinous body is ideal for withstanding the pressure down there but when brought to the surface it looks like a sad melted pink crayon.
#histology #science #pathology #pathologists #anatomy #autopsy #blobfish #embryology #premed #biology #dentalschool #dentalstudent #dentistry #medicaleducation #meded #nurse #nursing #medschool #medstudent #medicine #medlab #vetscience #vetschool #vetstudent #histologia #histotech #histo #pathArt #ihearthisto
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Caaaaarrrggghhh-diovascular Histology
Terrifying a medical student near you this Halloween!
The zombie’s lifeless eyes are arterioles.
His blood-filled mouth is a small vein.
All wrapped up in a connective tissue face.
Happy Halloween Histo fans!
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The Creepiest Fibroblast You Will Ever See
With a nucleus straight from the fiery depths of hell*
*Note: Fibroblasts do not come from hell. They are actually derived from embryonic mesoderm and the creepiest thing they do is secrete the collagen and ground substance of connective tissue. Not very creepy at all really when you think about it.
Histology is from the microscope of the ‘fiancee of ned4spd8834’
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