#sciblr
Ok so Haumea, a dwarf planet beyond Pluto, spins so fast it gets elongated like this. This is just what it looks like. Something deeply unsettles me looking at it. Terrifying.
this is so fucked up
This planet looks like a cool rock someone found in a creek.
one day it’s going to hatch and then all of you will be sorry
I look forward to meeting our dizzy, space hatchling overlord and/or destroyer.
Bone Marrow Cells (BMCs)
Whole bone marrow cells (BMCs) and bone marrow mononuclear cells (BMMCs) are the most accessible and studied source of stem cells.
- BMMCs are isolated from whole bone marrow, and contain a diverse cell population, including mesenchymal stem cells and hematopoietic progenitor cells.
Mesenchymal Stem Cells (MSCs)
MSCs can be isolated from a variety of tissues such as bone marrow, adipose, and umbilical cord; although it is not clear whether their properties are uniform (Selem, Hatzistergos and Hare, 2011).
MSCs are of particular note due to their immunoprivelegednature – a reduced expression of MHC class-I molecule, and lack of MHC class-II and co-stimulatory molecules, means they could potentially be used for allogeneic grafts (Zimmet et al., 2005). This means that they don’t produce an immune response and could be used in transplants - the body won’t reject them.
- MSCs inhibit the activity of various immune cells, including T cells, B cells, natural killer cells, and dendritic cells via cell to cell contacts and soluble factors (Laflamme and Murry, 2005).
Foetal and Umbilical Cord Cells
Embryonic stem cells (ESCs), the prototypical stem cell, can develop into all cell types in the body. However, the practical application of human ESCs remains limited due to ethical problems, teratoma formation (cancer), and immune rejection. With rapidly expanding knowledge of molecular and genetic pathways for ESC differentiation, it may become possible to avoid contamination with undifferentiated ESCs, thereby inhibiting teratogenesis when transplanted into the body (Kucia et al., 2006).
- Foetal-derived stem cells can also be isolated from the amniotic fluid, which include both pluripotent and committed stem cells.
- Umbilical cord cells can be gathered at birth and stored, eg if for treatment later on if a defect is detected in utero.
Induced pluripotent stem cells (iPSCs)
Induced pluripotent stem cells are a more attractive alternative to ESCs, as they are autologous. This means cells can be taken from an individual, ‘reset’ back to their stem cell stage, and then administered to that same individual to avoid rejection. Pluripotency transcription factors are introduced to adult terminally differentiated somatic cells, such as dermal fibroblasts, in a novel strategy which ‘reprograms’ the cells back to an embryonic stem cell-like stage (Yu et al., 2007).
Despite slight epigenetic differences associated with reprogramming, iPSCs fully resemble ESCs in terms of differentiation capacity, morphology and gene expression profile; and have the ability to differentiate into other cells. Ethical and immune response dilemmas are bypassed by the autologous nature of iPSCs, however clinical application is not yet on the horizon due to their teratogenic potential and the oncogenes and virus vectors required for the current method of pluripotent induction (Yamanaka and Takahashi, 2006).
Skeletal myoblasts (SM)
Skeletal myoblasts (satellite cells) are derived from skeletal muscle and have the capacity to differentiate into muscle fibre, which makes them obvious candidates for treating conditions such as heart damage following infarction. However, clinical trials have been halted as SM have been observed to couple with resident cardiomyocytes, resulting in dysfunctional electrocardiology and arrhythmias, and have struggled to transdifferentiate into cardiomyocytes in vivo (Reinecke, Poppa and Murry, 2002).
Stem cells are cells in the body that don’t yet have any role (undifferentiated or partially differentiated), and can change to become almost any cell type.
- Canproliferate (divide to make more cells) indefinitelyto make more of the same stem cells.
- They are the earliest type of cell in a cell lineage (if a cell was an adult human, stem cells would be the foetus)
- found in both embryonic and adult organisms, but they have slightly different properties in each
- Can also be made in a lab by reprogramming other cells - resetting them back to stem cell stage.
Inembryonic development (a baby forming in the womb), pluripotent stem cells develop at the blastocyst stage (3-4 days) and differentiate into all the cells of the human body as the foetus develops.
Stem cells do exist in the adult body, however they are not pluripotent - they are unipotent or multipotent - this means they can only differentiate into one or a few cell types respectively.
Adult stem cells
Adult stem cells are found in a few select locations in the body, known as niches, such as:
- the brain
- bone marrow
- blood and blood vessels
- skeletal muscles
- liver
- gonads
They exist to replenish rapidly lost cell types and include hematopoieticstem cells, which replenish blood and immune cells,basal cells, which maintain the skin epithelium, and mesenchymal stem cells, which maintain bone, cartilage, muscle and fat cells. Adult stem cells are a small minorityof cells.
Malignant lesions of the ovaries include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body.
Signs and symptoms
- Bloating; abdominal distention or mass
- Pressure effects on the bladder and rectum
- Constipation, indigestion, reflux
- Vaginal bleeding
- Shortness of breath, tiredness, weight loss
Diagnosis
Physical findings are uncommon in early stages. Advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction.
Pathophysiology
- Typicallyspreads to the peritoneal surfaces and omentum.
- Occurs via local extension, lymphatic invasion, intraperitoneal implantation, hematogenous dissemination, or transdiaphragmatic passage.
- Malignant cells can implant anywhere in the peritoneal cavity but are more likely to implant in sites of stasis along the peritoneal fluid circulation.
Epithelial tumours make up 90% of ovarian tumours. Other histologies include:
- Sex-cord stromal tumors
- Germ cell tumors
- Primary peritoneal carcinoma
- Metastatic tumors of the ovary
Epithelial ovarian cancer
- Arises from epithelium covering the fimbria of the fallopian tubes, or the ovaries, both of which are derived from the coelomic epithelium.
- Found primarily as cystic lesions with solid components.
- Surface may be smooth or covered in papillary projections.
- Cysts contain fluid from yellow to brown and haemorrhagic.
Four main histologic subtypes:
- Serous (from fallopian tube)
- Endometrioid (endometrium)
- Mucinous (cervix)
- Clear cell (mesonephros)
Tumours of low malignant potential
Tumours of low malignant potential (LMP) are a variety of much less aggressive epithelial ovarian cancer, with good prognosis.
LMP tumors can cause a range of symptoms similar to epithelial ovarian cancer, including increasing abdominal girth, an abdominal mass, abdominal pain, abnormal uterine bleeding, urinary symptoms, and gastrointestinal symptoms. They may be asymptomatic and found on routine physical examination or ultrasound scan.
The tongue is covered with many little bumps called papillae.Taste buds are found in the walls of papillae and the grooves surrounding them. Each taste bud contains anywhere from 50 to 150 taste receptor cells.
- Microvilliextend from taste receptor cells
- and protrude through an opening (taste pore) into the mouth.
- These microvilli come in contact with substances in the mouth that can be tasted, also known as tastants.
- Tastants interact with taste receptor cells through a number of different mechanisms to depolarize the cells.
- When taste cells are depolarized, they release neurotransmitters that stimulate sensory neurons that travel in cranial nerves VII, IX, and X.
- These neurons terminate on neurons in the nucleus of the solitary tract in the medulla then continue on to the thalamus.
- Taste information is sent to the gustatory cortex, ( ocated on the border between the anterior insula and the frontal operculum).
- This information encodes for basic tastes, such as sweet, salty, sour, bitter, and savory or umami.
- However, the actual flavour of a food—which is what we typically define as taste—is created by a combination of taste and olfactory (smell) information.
Sweetness
- Produced by the presence of sugars, some proteins, and other substances.
- Detected by G protein-coupled receptors T1R2+3 (heterodimer) and T1R3 (homodimer).
Saltiness
- Saltiness is a taste produced best by the presence of cations (such as Na+, K+or Li+)
- Directly detected by cation influx into glial like cells via leak channels causing depolarisation of the cell.
Sourness
- Sourness is acidity and is also sensed using ion channels.
- Undissociated acid diffuses across the plasma membrane of a presynaptic cell, where it dissociatesin accordance with Le Chatelier’s principle.
- Theprotons that are released then block potassium channels, which depolarise the cell and cause calcium influx.
Bitterness
- Current research suggests TAS2Rs (taste receptors, type 2, also known as T2Rs) such as TAS2R38 are responsible tasting bitter substances.
Savouriness
- The amino acid glutamic acid is responsible for savouriness, but some nucleotides (inosinic acid and guanylic acid) can act as complements.
- Glutamic acid binds to a variant of the G protein-coupled receptor, producing a savoury taste
Thethymus is a specialised primary lymphoid organ of the immune system.
- At its largest and most active during the neonatal and pre-adolescent periods.
- Decreases in size and activity through teenage years
- Thymus tissue is gradually replaced by adipose tissue(fat).
- Residual T lymphopoiesis continues throughout adult life.
The thymus is composed of two identical lobes and is located in the anterior superior mediastinum, in front of the heart and behind the sternum. Each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule.
Function
Facilitates the maturation of T cells - which provide cell-mediated immunity.
- T cells begin as hematopoietic precursors from the bone-marrow, and migrate to the thymus, where they are referred to as thymocytes.
- In the thymus they undergo a process to ensure the cells react against antigens (“positive selection”), but that they do not react against antigens found on body tissue(“negative selection”).
- Once mature, T cells emigrate from the thymus to provide vital functions in the immune system.
- Each T cell has a distinct T cell receptor, suited to a specific substance, called an antigen.
- Most T cell receptors bind to the major histocompatibility complex on cells of the body.
Positive selection
T cells have distinct T cell receptors. These are formed by process recombination gene rearrangement which is error-prone, and some thymocytes fail to make functional T-cell receptors, whereas other thymocytes make T-cell receptors that are autoreactive. The survival and nature of the T cell then depends on its interaction with surrounding thymic epithelial cells.
- T cell receptor interacts with the MHC molecules on the surface of epithelial cells.
- A T cell with a receptor that doesn’t react, or reacts weakly will die by apoptosis.
- A T cell that does react will survive and proliferate.
- A mature T cell expresses only CD4 or CD8, but not both.
Negative selection
T cells that attack the body’s own proteins are eliminated in the thymus. Epithelial cells in the medulla and dendritic cells in the thymus express major proteins from elsewhere in the body. Some CD4 positive T cells exposed to self antigens persist as T regulatory cells.
Pathology
Immunodeficiency - As the thymus is the organ of T-cell development, any congenital defect in thymic genesis or a defect in thymocyte development can lead to a profound T cell deficiency in primary immunodeficiency disease.
Autoimmune disease - Genetic disorders, such as Myasthenia gravis: caused by antibodies that block acetylcholine receptors.
Thymomas - Originate in thymic epithelial cells most often in adults older than 40. Generally detected when they cause symptoms, such as a neck mass or affecting nearby structures such as the superior vena cava. Can be benign; benign but by virtue of expansion, invading beyond the capsule of the thymus (“invasive thyoma”), or malignant (a carcinoma).
Lymphomas - Tumours originating from T cells of the thymus form a subset of acute lymphoblastic leukaemia (ALL)
Thymic cysts - The thymus may contain cysts, usually less than 4 cm in diameter. Thymic cysts are usually detected incidentally and do not generally cause symptoms.
““No, you cannot put a person in a bomb calorimeter.””— Exercise Physiology Professor, explaining the measurement of human energy expenditure
Who’s watching the launch of the Space X crew today? ⭐️
Meet Crew-1: These are the 4 astronauts who are flying on SpaceX’s next Crew Dragon
“Not even gravity contains humanity when we work one for all….”
LIFTOFF! ⭐️
Who’s watching the launch of the Space X crew today? ⭐️
Meet Crew-1: These are the 4 astronauts who are flying on SpaceX’s next Crew Dragon
Who’s watching the launch of the Space X crew today? ⭐️
Service
Judged a middle school county science fair today. I got to hand out ribbons to the kiddos who won! It was great :) Remember to always make some time in your busy grad student schedule to give back. That science fair win in 6th or 8th grade could help push that student into pursuing a career in science.
Reading for prelims - 12 days to go.
I think I printed out more than I actually got to read. There are three stacks of papers with scribbles down the margins and sticky notes all over my wall. Down the rabbit hope I go…..pls send coffee.